Mesothelioma — malignant (thicket) a tumor growing from мезотелиальной of a fabric, with sites from cages and аденоматозной fabrics. As a rule, a tumor find out in a pleura and a peritoneum, is more rare — in and joints. Grows as the thick layer covering an internal, and consists from cages and a fibrous fabric.
Risk factors: long contact to asbestos, smoking.
Classification • the Mesothelioma good-quality — a mesothelioma in the form of knot on a leg or the wide basis • the Mesothelioma malignant (a cancer) is characterized growth and propensity to early
Pleura mesothelioma (МКБ-10. C45.0 a pleura Mesothelioma)
• the Clinical picture: a short wind (connected with pleurisy), pains in a thorax (owing to tumor germination in), cough and a blood spitting, decrease in weight of a body. Diagnostics: survey thorax bodies; a pleural puncture, evacuation of an exudate and its cytologic research; and a tumor biopsy.
середа, 4 серпня 2010 р.
вівторок, 29 червня 2010 р.
Asbestos mesothelioma complaint filed at Holyoke High School
The federal Occupational Safety and Health Administration is investigating an anonymous complaint that workers had uncovered high levels of asbestos while working on a renovation project at Holyoke High School in Holyoke, Massachusetts.
The project manager on site, however, has assured that testing was completed. He noted that regulations have been followed throughout the year, and that both the air and dust were tested.
School Superintendent Eduardo B. Carballo noted, “These are serious allegations...but I am assured by the manager of the project that they are going to check it out,” reports MassLive.com.
Additional tests have been planned in light of the complaint, and school officials have assured parents that students are safe.
If high levels of asbestos were released in the air, however, it would put those exposed at risk for contracting diseases such as asbestosis, lung cancer and mesothelioma. Mesothelioma is the most rare and aggressive form of diseases to arise from asbestos exposure--and affects the chest, heart and abdominal cavities.
Mesothelioma doctors struggle to diagnose patients early on with the disease, and find difficulty in treating patients. Palliative treatment options, such as chemo, may extend the life of a patient, but there is currently no known mesothelioma cure.
Company owner of Samsyd Window and Door Co., John Samysd, noted that one of his employees asked for caulk surrounding the high school’s windows to be tested for asbestos. Three of the four samples tests displayed high levels of asbestos.
Project designer for Forbes & Wheeler, Stephen W. Niec, said his firm had regularly tested the air and dust at the high school. However, Niec noted that, in light of the complaint, he would be returning to the high school to complete more tests.
The project manager on site, however, has assured that testing was completed. He noted that regulations have been followed throughout the year, and that both the air and dust were tested.
School Superintendent Eduardo B. Carballo noted, “These are serious allegations...but I am assured by the manager of the project that they are going to check it out,” reports MassLive.com.
Additional tests have been planned in light of the complaint, and school officials have assured parents that students are safe.
If high levels of asbestos were released in the air, however, it would put those exposed at risk for contracting diseases such as asbestosis, lung cancer and mesothelioma. Mesothelioma is the most rare and aggressive form of diseases to arise from asbestos exposure--and affects the chest, heart and abdominal cavities.
Mesothelioma doctors struggle to diagnose patients early on with the disease, and find difficulty in treating patients. Palliative treatment options, such as chemo, may extend the life of a patient, but there is currently no known mesothelioma cure.
Company owner of Samsyd Window and Door Co., John Samysd, noted that one of his employees asked for caulk surrounding the high school’s windows to be tested for asbestos. Three of the four samples tests displayed high levels of asbestos.
Project designer for Forbes & Wheeler, Stephen W. Niec, said his firm had regularly tested the air and dust at the high school. However, Niec noted that, in light of the complaint, he would be returning to the high school to complete more tests.
Asbestos abatement to occur at Maryland schools prior to large renovation project
Many Washington County Public Schools will undergo improvements this summer, and it will reportedly cost more than $10.9 million for the list of Maryland schools to improve several sections of their buildings, according to the Herald Mail.
The majority of projects are expected to conclude this summer. However, two heating, ventilation and air conditioning projects, at Boonsboro Middle School and Emma K. Doub School for Integrate Arts & Technology, have been postponed until 2011.
Work at Funkstown School for Early Childhood Education will carry into the fall.
Asbestos abatement is set to occur at E. Russell Hicks Middle School, Emma K. Doub School for Integrated Arts & Technology, Smithsburg High School, Western Heights Middle School, Williamsport High School and Winter Street Elementary School.
The asbestos removal must occur before any further improvements or renovations may begin. When asbestos is disturbed, without first being properly removed, toxic particles are released into the air. When the asbestos particles are inhaled, those exposed are put at serious risk for contracting asbestosis, lung cancer, or even worse, mesothelioma.
Mesothelioma is a rare and aggressive disease which affects nearly 3,000 Americans each year.
Symptoms of the disease lie dormant for several decades, and because of this, mesothelioma doctors struggle to diagnose patients with the disease early on. There is no mesothelioma cure.
Director of maintenance and operations, Mark J. Mills, noted that the school system is sharing the total projects’ cost. However, a few projects, such as window replacements, have other funding sources.
The majority of projects are expected to conclude this summer. However, two heating, ventilation and air conditioning projects, at Boonsboro Middle School and Emma K. Doub School for Integrate Arts & Technology, have been postponed until 2011.
Work at Funkstown School for Early Childhood Education will carry into the fall.
Asbestos abatement is set to occur at E. Russell Hicks Middle School, Emma K. Doub School for Integrated Arts & Technology, Smithsburg High School, Western Heights Middle School, Williamsport High School and Winter Street Elementary School.
The asbestos removal must occur before any further improvements or renovations may begin. When asbestos is disturbed, without first being properly removed, toxic particles are released into the air. When the asbestos particles are inhaled, those exposed are put at serious risk for contracting asbestosis, lung cancer, or even worse, mesothelioma.
Mesothelioma is a rare and aggressive disease which affects nearly 3,000 Americans each year.
Symptoms of the disease lie dormant for several decades, and because of this, mesothelioma doctors struggle to diagnose patients with the disease early on. There is no mesothelioma cure.
Director of maintenance and operations, Mark J. Mills, noted that the school system is sharing the total projects’ cost. However, a few projects, such as window replacements, have other funding sources.
неділя, 16 травня 2010 р.
HOW DID I GET IT?
The only known cause of mesothelioma is exposure to asbestos. Mesothelioma results from breathing microscopic asbestos fibers into the lungs. When breathed into the lungs, asbestos tears the lung tissue. Because asbestos was very inexpensive, asbestos was used as a filler in many different products. For example, asbestos was used in cements, drywall muds, brake and clutch linings, roof shingles, gaskets, flooring products, paints, textiles and insulation. The fibers cause the lungs to form scar tissue again and again (asbestosis) or can cause lung cancer. If asbestos fibers damage mesothelial tissue, it may lead to mesothelioma.
Smoking does not cause mesothelioma. However, studies show that someone who was a smoker and was exposed to asbestos, is more likely to suffer from mesothelioma than a non-smoker.
Generally, it takes 20 to 50 years from the time of asbestos exposure until symptoms appear or mesothelioma is diagnosed. This time is called the "latency" period.
Mesothelioma is a serious disease. Half of the patients diagnosed at an early stage and treated aggressively live two years from the date of the diagnosis. One in five are still alive five years after diagnosis. Some patients live more than five years after diagnosis, but generally only if they have been diagnosed at an early date.
WHAT IS MESOTHELIOMA?
Mesothelioma is a cancer of the mesothelium; the protective sac that covers and protects most internal organs of the body. The mesothelium has two layers, one, which covers the organ, and a second, which forms a sac around it. The mesothelium has different names depending on the location in the body. The pleura is the name for the mesothelial tissue surrounding the lungs and lining the chest cavity. The peritoneum covers most of the organs in the abdominal cavity, while the pericardium covers and protects the heart.
The mesothelium produces a lubricating fluid that allows organs within it to move and glide easily. The fluid allows the lungs to breathe and the heart to expand and contract without creating any type of internal friction.
Like other forms of cancer, mesothelioma occurs when cells become abnormal and divide or grow out of control. When someone has mesothelioma, the helpful lubricating fluid described above may be over-produced. This excess fluid encases the organs with a thick layer of tumor tissue, described as a rind type of layer. In advanced cases of mesothelioma, cells metastasize, or grow and invade other organs and spread to other areas of the body.
The majority of individuals suffering from mesothelioma have cancer in the lining of the lung. Sometimes, mesothelioma occurs in the lining of the abdominal cavity (peritoneal mesothelioma) or in the lining of the heart (pericardial mesothelioma).
The symptoms of mesothelioma are common to a number of illnesses which means that mesothelioma is difficult to diagnose. Unique types of treatment for mesothelioma are still being investigated through clinical trials and research, but as a general rule, mesothelioma does not respond well to most treatments that are currently being offered.
Mesothelioma is caused by breathing or ingesting asbestos fibers. The coarse fibers cause scarring of the mesothelial tissue which can cause asbestosis or pleural plaques. Unfortunately, the scarring can also lead to cancer known as mesothelioma.
It often takes 20 to 50 years after exposure to asbestos before the symptoms of mesothelioma develop. This period of time is referred to as a latency period. Because of the latency period, the disease commonly affects men and women that are at least 50 years of age and that worked with asbestos between 20 and 50 years ago. Many workers working 20 to 50 years ago did not use any type of protection in the workplace while they were exposed to the dust or fibers from asbestos. At the same time, however, many of the companies employing the workers had full knowledge that asbestos was dangerous and that exposure to asbestos would harm the health of many of the workers. Insulators, plasterers, electricians, pipefitters, mechanics, ironworkers, ship builders, ship workers, brick layers, carpenters, and other tradesmen are just a few examples of workers that were likely to work with asbestos on a day-to-day basis. Also at risk are the families of these workers, as the asbestos fibers may be brought into the home from the clothes, skin, or hair of the worker.
Unfortunately, millions of people have been exposed to asbestos over the years. Only now are we able to see the disastrous effects of asbestos exposure in the workplace.
As with other cancers, a speedy diagnosis is important to effective treatment of mesothelioma. If you believe that you may have mesothelioma and that you worked with asbestos in the past, you may wish to inform your doctor of this fact.
вівторок, 30 березня 2010 р.
About Mesothelioma
About Mesothelioma
Mesothelioma is a rare form of cancer that develops in the mesothelial cells. These cells are tissue that surround or line the lungs, heart, and stomach. The mesothelial cells protect these organs by producing a lubricating fluid that allows these organs to move smoothly.
Malignant mesotheliomas arise from the cells that line the surface of the pleura or the peritoneum. Eighty percent of these tumors are pleural in origin. Malignant mesotheliomas are rare, with an incidence of one to three cases per 1 million persons per year in the general population. Approximately 2000 new cases are diagnosed each year.
The relationship between asbestos exposure and malignant mesothelioma was established in 1960. The latency period between exposure and tumor development has usually been 30 years or more.
The incidence of malignant mesothelioma has been highest in persons with heavy occupational exposure to asbestos, such as shipyard workers. However, malignant mesothelioma can occur in the absence of any known asbestos exposure. No history of such exposure has been noted in about one-third of cases, and the etiology of these cases is usually unknown. Some cases of mesothelioma have been diagnosed in family members of asbestos workers and people who reside near asbestos mines. Cigarette smoking is not considered a risk factor for malignant mesothelioma.
The patient with malignant mesothelioma of the pleura may have symptoms of dyspnea (shortness of breath)and pleuritic chest pain (pain with breathing), with malaise and weight loss. A large pleural effusion is often seen on the radiograph. This effusion which is a collection of fluid between the lungs and the chest is frequently bloody, and the hyaluronic acid level may be elevated. Associated parenchymal fibrosis (asbestosis) is rare in pleural mesothelioma but appears to be more common in peritoneal mesothelioma.
Malignant mesothelioma can be very difficult to diagnose, although medical advances have made it somewhat easier. A CAT scan or an MRI scan may show the cancer; If the cancer is in the chest, a surgeon can make a small incision between two ribs and insert a tiny instrument with a light and a camera inside, and take samples with this instrument. If the cancer is in the abdomen, a similar procedure, called a peritoneoscopy can be performed. Actual open biopsy is only necessary if there is no other way to obtain tissue,
There is no 100% effective treatment for malignant mesothelioma. Complete surgical resection is not possible in most cases. In many cases, part of the pleura and part of the tumor can be removed, surgery which decreases symptoms. The tumor encases the lung in a bulky, lobulated mass that invades the fissures and, eventually, the diaphragm and the chest wall. Average survival is one to two years. Except in rare cases, chemotherapy and radiation therapy have not been useful. Despite these facts however, there have been patients who have lived longer because of emerging treatments, and earlier diagnosis.
Anna L. Kaplan, M.D.
Type of Pleural Effusion Important for Mesothelioma Diagnosis
by Nancy Meredith
Pleural effusions are found in 95% of all pleural mesothelioma cases. When a patient presents to a doctor with pleural effusion, however, there are many other diseases which could cause the fluid buildup. There are multiple medical tests that should be conducted by the physician to determine the cause, but when exudative pleural effusion is identifed, the type associated with lung disease, a patient history to assess the possibility of asbestos exposure is important.
Pleural mesothelioma is a form of lung cancer that is almost always caused by asbestos exposure and is most commonly found in the outer lining of the lungs called the mesothelium. Due to the long latency period most cases of mesothelioma are diagnosed 30 years or more after exposure.
A pleural effusion is an accumulation of fluid between the layers of tissue that line the lungs and chest cavity. In healthy adults the body produces pleural fluid in small amounts to lubricate the surfaces of the pleura. This fluid is normally removed by lymphatics in the parietal pleura, which have the capacity to absorb 20 times more fluid than is normally formed. When this capacity is overwhelmed, a pleural effusion develops.
Transudative Effusions vs Exudative Effusions
Determining the cause and type of the pleural effusion is critical in treating the underlying disease as well as determining the appropriate method to clear the fluid from the chest cavity. A lung surrounded by excess fluid for too long may collapse.
There are two types of effusions: transudative effusions and exudative effusions.
Due to elevated pressure or low protein content in the blood vessels, fluid leaks into the pleural space causing transudative effusions. Systemic factors that alter the balance of the formation and absorption of pleural fluid, such as pulmonary embolism and cirrhosis, are the root of transudative effusions. Congestive heart failure is the most common cause of transudative effusions. Other causes include constrictive pericarditis and peritoneal dialysis.
Leaky blood vessels caused by inflammation involving irritation and swelling of the pleura and alterations in local factors that influence the formation and absorption of pleural fluid result in exudative effusions. Exudative pleural effusions are associated with asbestos-related diseases such as mesothelioma and asbestosis. The effusions are often caused by other lung diseases, including lung cancer, lung infections such as tuberculosis and pneumonia, and drug reactions.
Light's Criteria
According to The Merck Manuals the path to take in diagnosing the disease causing pleural effusion includes using Light's Criteria. This set of criteria was developed by Dr. Richard Light, Pulmonary Disease Physician and Professor of Medicine at The Vanderbilt Clinic, Nashville, TN, and Director of Pulmonary Disease Program, St Thomas Hospital, Nashville.
The two effusions are differentiated by comparing chemistries in the pleural fluid to those in the blood. Light's Criteria looks at the ratio of pleural fluid protein to serum protein, the ratio of pleural fluid LDH to serum LDH, and whether the pleural fluid LDH is more than two-thirds the normal upper limit for serum. If the criteria are met then exudative effusion is assumed and additional evaluation is needed to determine the cause of the excess fluid.
Personal History
Dr. Light agrees with his colleague Gary Lee, Consultant Physician & Senior Lecturer, Osler Chest Unit, Churchill Hospital, Oxford, UK when he says that it is important to go beyond Light's Criteria and get a detailed history of the patient so the treating physician knows what to do with the exudative identification.
Since X-rays, CT scans and potentially ultrasound have all been performed leading up to confirming that the patient has pleural effusion, and further tests confirm that the effusion is exudative in nature, if the patient's history reveals exposure to asbestos the doctor may be able to move to tests to eliminate or confirm an asbestos-related disease by checking mesothelial levels.
Injury (inflammation) to the mesothelium triggers events leading to the migration of mesothelial cells from the edge of the lesion towards the wound center, causing an increase in levels. Neoplastic transformation (conversion of a tissue with a normal growth pattern into a malignant tumor) of mesothelial cells gives rise to malignant mesothelioma.
Contact a Specialist
Due to mesothelioma’s relative rarity among the general population, it is recommended that if you are diagnosed with mesothelioma that you be treated by a team of doctors and surgeons led by a mesothelioma specialist. Mesothelioma specialists are aware of the latest research and they are able to develop a more informed treatment plan than would a physician who does not specialize in the disease.
Sources:
Pleural Effusion
Definition of Pleural Effusion
Pleural effusions are found in 95% of all pleural mesothelioma cases. When a patient presents to a doctor with pleural effusion, however, there are many other diseases which could cause the fluid buildup. There are multiple medical tests that should be conducted by the physician to determine the cause, but when exudative pleural effusion is identifed, the type associated with lung disease, a patient history to assess the possibility of asbestos exposure is important.
Pleural mesothelioma is a form of lung cancer that is almost always caused by asbestos exposure and is most commonly found in the outer lining of the lungs called the mesothelium. Due to the long latency period most cases of mesothelioma are diagnosed 30 years or more after exposure.
A pleural effusion is an accumulation of fluid between the layers of tissue that line the lungs and chest cavity. In healthy adults the body produces pleural fluid in small amounts to lubricate the surfaces of the pleura. This fluid is normally removed by lymphatics in the parietal pleura, which have the capacity to absorb 20 times more fluid than is normally formed. When this capacity is overwhelmed, a pleural effusion develops.
Transudative Effusions vs Exudative Effusions
Determining the cause and type of the pleural effusion is critical in treating the underlying disease as well as determining the appropriate method to clear the fluid from the chest cavity. A lung surrounded by excess fluid for too long may collapse.
There are two types of effusions: transudative effusions and exudative effusions.
Due to elevated pressure or low protein content in the blood vessels, fluid leaks into the pleural space causing transudative effusions. Systemic factors that alter the balance of the formation and absorption of pleural fluid, such as pulmonary embolism and cirrhosis, are the root of transudative effusions. Congestive heart failure is the most common cause of transudative effusions. Other causes include constrictive pericarditis and peritoneal dialysis.
Leaky blood vessels caused by inflammation involving irritation and swelling of the pleura and alterations in local factors that influence the formation and absorption of pleural fluid result in exudative effusions. Exudative pleural effusions are associated with asbestos-related diseases such as mesothelioma and asbestosis. The effusions are often caused by other lung diseases, including lung cancer, lung infections such as tuberculosis and pneumonia, and drug reactions.
Light's Criteria
According to The Merck Manuals the path to take in diagnosing the disease causing pleural effusion includes using Light's Criteria. This set of criteria was developed by Dr. Richard Light, Pulmonary Disease Physician and Professor of Medicine at The Vanderbilt Clinic, Nashville, TN, and Director of Pulmonary Disease Program, St Thomas Hospital, Nashville.
The two effusions are differentiated by comparing chemistries in the pleural fluid to those in the blood. Light's Criteria looks at the ratio of pleural fluid protein to serum protein, the ratio of pleural fluid LDH to serum LDH, and whether the pleural fluid LDH is more than two-thirds the normal upper limit for serum. If the criteria are met then exudative effusion is assumed and additional evaluation is needed to determine the cause of the excess fluid.
Personal History
Dr. Light agrees with his colleague Gary Lee, Consultant Physician & Senior Lecturer, Osler Chest Unit, Churchill Hospital, Oxford, UK when he says that it is important to go beyond Light's Criteria and get a detailed history of the patient so the treating physician knows what to do with the exudative identification.
Since X-rays, CT scans and potentially ultrasound have all been performed leading up to confirming that the patient has pleural effusion, and further tests confirm that the effusion is exudative in nature, if the patient's history reveals exposure to asbestos the doctor may be able to move to tests to eliminate or confirm an asbestos-related disease by checking mesothelial levels.
Injury (inflammation) to the mesothelium triggers events leading to the migration of mesothelial cells from the edge of the lesion towards the wound center, causing an increase in levels. Neoplastic transformation (conversion of a tissue with a normal growth pattern into a malignant tumor) of mesothelial cells gives rise to malignant mesothelioma.
Contact a Specialist
Due to mesothelioma’s relative rarity among the general population, it is recommended that if you are diagnosed with mesothelioma that you be treated by a team of doctors and surgeons led by a mesothelioma specialist. Mesothelioma specialists are aware of the latest research and they are able to develop a more informed treatment plan than would a physician who does not specialize in the disease.
Sources:
Pleural Effusion
Definition of Pleural Effusion
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